Saints suffered their first defeat on the road since the opening day of the season (at Crystal Palace).
Goals from James Maddison and Harvey Barnes enough to secure Leicester City a 2-0 win.
Having not played for two weeks - and, more importantly, missing a number of key players - it always looked like being a tough ask for Ralph Hasenhüttl's side.
While there was plenty of effort across the 90 minutes, creativity in the attacking third was lacking again. Just one goal for Saints in their last five Premier League matches.
The result leaves them 8th in the table.
Shortly after full-time, Glen provided his latest GDLC Player Ratings:
Alex McCarthy - 7
Kyle Walker-Peters - 7
Jan Bednarek - 8
Jack Stephens - 5
Ryan Bertrand - 8 (GDLC Man of the Match)
James Ward-Prowse - 7
Ibrahima Diallo - 7
Stuart Armstrong - 7
Will Smallbone - 7
Theo Walcott - 6
Che Adams - 7