Saints put in a committed effort against Manchester City, however eventually ended up on the wrong end of a 1-0 scoreline - with Raheem Sterling's first-half strike enough to secure all 3 points for Pep Guardiola's team.
Despite that, Ralph Hasenhüttl was proud that his side again put in a decent performance against a vastly more financed 'Big 6' Club.
While Saints lacked a real cutting edge, particularly once Danny Ings went off injured, what did Glen de la Cour make of the overall contributions?
Here are his latest GDLC Player Ratings:
Alex McCarthy - 8
Kyle Walker-Peters - 8
Jan Bednarek - 7
Jannik Vestergaard - 9 (GDLC Man of the Match)
Ryan Bertrand - 7
James Ward-Prowse - 8
Oriol Romeu - 8
Moussa Djenepo - 6
Ché Adams - 6
Theo Walcott - 8
Danny Ings - 6