Saints set an unwanted Club record by suffering their sixth league defeat in a row.
Despite Danny Ings fantastic first-half volley, Wolves fought back after the break to take all three points.
While Saints have been largely impacted by injuries over the past month or so, it was pretty much their strongest side against Wolves, meaning the defeat felt even harder to take.
With Chelsea, Leeds and Everton around the corner, life doesn't look like getting any easier for Ralph Hasenhüttl and his team.
Glen provided his post-match GDLC Player Ratings (averaged out across two halves...!):
Alex McCarthy - 6
Jannik Vestergaard - 6.5
Jan Bednarek - 6
Kyle Walker-Peters - 6.5
Ryan Bertrand - 6
James Ward-Prowse - 6.5
Oriol Romeu - 5.5
Takumi Minamino - 5.5
Nathan Redmond - 6
Stuart Armstrong - 7 (GDLC Man of the Match)
Danny Ings - 6.5